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Table 1 Screening results at 6 consecutive 2-year screening periods

From: Trends in incidence and detection of advanced breast cancer at biennial screening mammography in The Netherlands: a population based study

Screening period

1997/1998

1999/2000

2001/2002

2003/2004

2005/2006

2007/2008

Total

Mammograms, No

48,721

53,718

53,489

61,251

66,300

67,530

351,009

Referral, No

536

499

553

985

874

1003

4450

Referral rate, % (95% CI)

1.1 (1.0-1.2)

0.9 (0.9-1.0)

1.0 (1.0-1.1)

1.6 (1.5-1.7)

1.3 (1.2-1.4)

1.5 (1.4-1.6)

1.3 (1.2-1.3)

Screen detected breast cancers, No

224

274

254

345

321

353

1,771

   Advanced cancers, No (rate*; 95% CI)

74

(1.5; 1.2-1.9)

87

(1.6; 1.3-2.0)

88

(1.6; 1.3-2.0)

99

(1.6; 1.3-1.9)

97

(1.5; 1.2-1.8)

125

(1.9; 1.5-2.2)

570

(1.6; 1.5-1.8)

   Non-advanced cancers, No (rate*; 95% CI)

147

(3.0; 2.5-3.5)

178

(3.3; 2.8-3.8)

160

(3.0; 2.5-3.5)

239

(3.9; 3.4-4.4)

218

(3.3; 2.9-3.7)

222

(3.3; 2.9-3.7)

1,164

(3.3; 3.1-3.5)

   Unknown tumor stage, No (rate*; 95% CI)

3

(0.1; 0.0-0.1)

9

(0.2; 0.1-0.3)

6

(0.1; 0.0-0.2)

7

(0.1; 0.0-0.2)

6

(0.1; 0.0-0.2)

6

(0.1; 0.0-0.2)

37

(0.1; 0.1-0.1)

Cancer detection rate* (95% CI)

4.6 (4.0-5.2)

5.1 (4.5-5.7)

4.7 (4.2-5.3)

5.6 (5.0-6.2)

4.8 (4.3-5.4)

5.2 (4.7-5.8)

5.1 (4.8-5.3)

PPV of referral, % (95% CI)

41.8 (37.6-46.0)

54.9 (50.8-59.5)

45.9 (41.9-50.2)

35.0 (32.0-38.0)

36.7 (33.5-39.9)

35.2 (32.1-38.0)

39.8 (38.3-41.2)

Interval cancers, No

75

94

128

116

139

117

669

   Advanced cancers, No (rate*; 95% CI)

39

(0.8; 0.5-1.1)

63

(1.2; 0.9-1.5)

86

(1.6; 1.3-1.9)

79

(1.3; 1.0-1.6)

87

(1.3; 1.0-1.6)

70

(1.0; 0.8-1.3)

424

(1.2; 1.1-1.3)

   Non-advanced cancers, No (rate*; 95% CI)

33

(0.7; 0.4-0.9)

30

(0.6; 0.4-0.8)

39

(0.7; 0.5-1.0)

35

(0.6; 0.4-0.8)

50

(0.8; 0.5-1.0)

46

(0.7; 0.5-0.9)

233

(0.7; 0.6-0.7)

   Unknown tumor stage, No (rate*; 95% CI)

3

(0.1; 0.0-0.1)

1

(0.0; 0.0-0.1)

3

(0.1; 0.0-0.1)

2

(0.0; 0.0-0.1)

2

(0.0; 0.0-0.1)

1

(0.0; 0.0-0.0)

12

(0.0; 0.0-0.1)

Sensitivity, % (95% CI)

74.9 (70.3-80.1)

74.5 (70.0-78.9)

66.5 (61.8-71.2)

74.8 (70.9-78.8)

69.8 (65.6-74.0)

75.1 (72.0-79.8)

72.6 (71.0-74.5)

Proportion of advanced cancers among screen detected cancers + interval cancers, % (95% CI)

37.8 (32.4-43.4)

40.7 (36.3-46.3)

45.5 (40.0-50.0)

38.6 (34.2-43.1)

39.9 (35.7-44.7)

41.5 (37.0-46.0)

40.7 (38.8-42.7)

  1. *per 1,000 women screened; CI = confidence interval; PPV = positive predictive value
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