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Table 3 Polymorphisms in mitotic pathway genesa and percent mammographic density among MCBCSb (n = 484) and SASBACb(n = 726) controls.

From: No evidence for association of inherited variation in genes involved in mitosis and percent mammographic density

     

MCBCS

SASBAC

 

Chr

Gene Name

Effect

SNP

Position (bp)

N

PMD

Est (SE)/

adj meanc

P-valued

N

Sqrt PMD Est (SE)/

adj meane

P-valued

P-Hetf

1

GALNT2

Ordinal

rs1043908

228483917

484

2.88 (1.28)

0.025

725

-0.314 (0.135)

0.02

< 0.001

  

A/A

  

373

17.9

 

555

19.0

  
  

A/G

  

102

20.8

 

158

16.3

  
  

G/G

  

9

23.6

 

12

13.9

  

2

LOC375190

Ordinal

rs2080727

24204411

484

1.69 (0.85)

0.048

725

0.185 (0.095)

0.05

0.54

  

A/A

  

195

17.2

 

305

17.1

  
  

A/G

  

215

19.4

 

332

18.7

  
  

G/G

  

74

20.2

 

88

20.3

  

6

MCM3

Ordinal

rs3765447

52249471

483

3.62 (1.76)

0.040

725

0.45 (0.188)

0.017

0.96

  

A/A

  

422

18.2

 

644

17.7

  
  

A/G

  

60

22.3

 

76

21.7

  
  

G/G

  

1

12.7

 

5

26.1

  

8

TNKS

Ordinal

rs12549064

9479437

484

-2.15 (1.09)

0.048

725

0.321 (0.116)

0.006

0.001

  

A/A

  

303

19.5

 

496

17.8

  
  

A/C

  

166

17.4

 

205

20.6

  
  

C/C

  

15

15.1

 

24

23.6

  

10

KIF11

Ordinal

rs2275220

94362686

484

-4.23 (2.12)

0.046

726

0.45 (0.172)

0.009

0.005

  

A/A

  

448

19.0

 

613

17.9

  
  

A/G

  

34

13.5

 

111

22.0

  
  

G/G

  

2

20.4

 

2

26.4

  

11

STIM1

Ordinal

rs3794050

4068476

484

2.85 (1.38)

0.039

726

-0.383 (0.142)

0.007

0.003

  

G/G

  

389

17.8

 

547

19.4

  
  

G/A

  

89

23.0

 

173

16.2

  
  

A/A

  

6

8.6

 

6

13.3

  

17

AURKB

Ordinal

rs3027260

8053911

484

-3.33 (1.52)

0.029

726

-0.404 (0.177)

0.022

0.73

  

G/G

  

404

19.2

 

632

18.7

  
  

G/A

  

77

15.8

 

91

15.4

  
  

A/A

  

3

12.8

 

3

12.4

  
  

Ordinal

rs4792590

8057840

484

-3.14 (1.34)

0.020

726

-0.39 (0.152)

0.010

0.89

  

G/G

  

377

19.3

 

597

18.6

  
  

G/A

  

102

16.6

 

121

15.4

  
  

A/A

  

5

9.5

 

8

12.5

  
  1. aP ≤ 0.05 in both studies. bMayo Clinic Breast Cancer Study; Singapore and Sweden Breast Cancer Study.
  2. cPMD Est(SE): ordinal parameter estimate and standard error reflecting the estimated change in percent density per each additional copy of the minor allele carried. Adjusted mean from general model: least squares estimate of mean percent density for each genotype, adjusted for age, BMI, and PMH. dP-value from analyses adjusted for age, BMI, and PMH. eSqrt PMD Est(SE): ordinal parameter estimate and standard error reflecting the estimated change in percent density error per each additional copy of the minor allele carried. Adjusted mean from general model: least squares estimate of mean percent density for each genotype, adjusted for age, BMI, and PMH. Least squares means back transformed from square root to original scale. fP-value from test for heterogeneity from meta-analysis performed on the ordinal parameter estimates (ordinal estimates for the MCBCS sample were estimated using square root transformed PMD).