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Table 3 Polymorphisms in mitotic pathway genesa and percent mammographic density among MCBCSb (n = 484) and SASBACb(n = 726) controls.

From: No evidence for association of inherited variation in genes involved in mitosis and percent mammographic density

      MCBCS SASBAC  
Chr Gene Name Effect SNP Position (bp) N PMD Est (SE)/ adj meanc P-valued N Sqrt PMD Est (SE)/ adj meane P-valued P-Hetf
1 GALNT2 Ordinal rs1043908 228483917 484 2.88 (1.28) 0.025 725 -0.314 (0.135) 0.02 < 0.001
   A/A    373 17.9   555 19.0   
   A/G    102 20.8   158 16.3   
   G/G    9 23.6   12 13.9   
2 LOC375190 Ordinal rs2080727 24204411 484 1.69 (0.85) 0.048 725 0.185 (0.095) 0.05 0.54
   A/A    195 17.2   305 17.1   
   A/G    215 19.4   332 18.7   
   G/G    74 20.2   88 20.3   
6 MCM3 Ordinal rs3765447 52249471 483 3.62 (1.76) 0.040 725 0.45 (0.188) 0.017 0.96
   A/A    422 18.2   644 17.7   
   A/G    60 22.3   76 21.7   
   G/G    1 12.7   5 26.1   
8 TNKS Ordinal rs12549064 9479437 484 -2.15 (1.09) 0.048 725 0.321 (0.116) 0.006 0.001
   A/A    303 19.5   496 17.8   
   A/C    166 17.4   205 20.6   
   C/C    15 15.1   24 23.6   
10 KIF11 Ordinal rs2275220 94362686 484 -4.23 (2.12) 0.046 726 0.45 (0.172) 0.009 0.005
   A/A    448 19.0   613 17.9   
   A/G    34 13.5   111 22.0   
   G/G    2 20.4   2 26.4   
11 STIM1 Ordinal rs3794050 4068476 484 2.85 (1.38) 0.039 726 -0.383 (0.142) 0.007 0.003
   G/G    389 17.8   547 19.4   
   G/A    89 23.0   173 16.2   
   A/A    6 8.6   6 13.3   
17 AURKB Ordinal rs3027260 8053911 484 -3.33 (1.52) 0.029 726 -0.404 (0.177) 0.022 0.73
   G/G    404 19.2   632 18.7   
   G/A    77 15.8   91 15.4   
   A/A    3 12.8   3 12.4   
   Ordinal rs4792590 8057840 484 -3.14 (1.34) 0.020 726 -0.39 (0.152) 0.010 0.89
   G/G    377 19.3   597 18.6   
   G/A    102 16.6   121 15.4   
   A/A    5 9.5   8 12.5   
  1. aP ≤ 0.05 in both studies. bMayo Clinic Breast Cancer Study; Singapore and Sweden Breast Cancer Study.
  2. cPMD Est(SE): ordinal parameter estimate and standard error reflecting the estimated change in percent density per each additional copy of the minor allele carried. Adjusted mean from general model: least squares estimate of mean percent density for each genotype, adjusted for age, BMI, and PMH. dP-value from analyses adjusted for age, BMI, and PMH. eSqrt PMD Est(SE): ordinal parameter estimate and standard error reflecting the estimated change in percent density error per each additional copy of the minor allele carried. Adjusted mean from general model: least squares estimate of mean percent density for each genotype, adjusted for age, BMI, and PMH. Least squares means back transformed from square root to original scale. fP-value from test for heterogeneity from meta-analysis performed on the ordinal parameter estimates (ordinal estimates for the MCBCS sample were estimated using square root transformed PMD).