MTEC genotype | |||||
---|---|---|---|---|---|
Estimated cell frequency | HIF-1α WT tumor-positive | HIF-1α-KO tumor-negative | HIF-1α WT | HIF-1α-KO | P valuesb |
Number of cells injected, % (n) | |||||
500 | 78% (7 of 9) | 0% (0 of 8) | 0.0023 | ||
200 | 90% (9 of 10) | 10% (1 of 10) | 0.0011 | ||
100 | 77% (10 of 13) | 9% (1 of 11) | 0.0003 | ||
50 | 69% (11 of 16) | 6% (1 of 16) | 0.0006 | ||
25 | 30% (6 of 20) | 0% (0 of 20) | 0.0202 | ||
10 | 35% (8 of 23) | 0% (0 of 22) | 0.0038 | ||
Estimated TIC frequency by ELDA (95% CI) | 1 of 82 (1 of 57 to 1 of 117) | 1 of 2,915 (1 of 925 to 1 of 9,193) | 5.79e-21 |