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Table 4 Mitotic scores (MSs), training and validation sets, and Ki-67LI descriptive measures in BC molecular classes

From: Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer

 

Luminal number (%)

HER2+ number (%)

TN number (%)

Total a

967 (69.9)

193 (13.6)

240 (16.5)

Mitosis scores

    

   1

318 (48.8)

16 (12.5)

4 (2.5)

   2

143 (22)

29 (22.7)

8 (5)

   3

190 (29.2)

83 (64.8)

148 (92.5)

Training set b

316 (33)

65 (33)

80 (33%)

Validation set b

651 (67)

128 (67)

160 (67)

Ki-67LI in the validation sets

    

   Ki-67 mean (SD)

22 (24.6)

41.5 (27.4)

64.5 (32)

   Ki-67LI median (range)

11 (0-98)

39.5 (0-97)

77 (1-98)

   Ki-67LI Cut-off

10

50

70

-

  1. aThis percentage is relative to the whole patients' series (that is, 1,457 cases). bThis percentage is relative to number of cases within the same class.
  2. Using 10% and 50% Ki-67LI cut offs divided the luminal class into low (46.9%), moderate (41.6%), and high (11.5%) proliferation subgroups, respectively.
  3. Ki-67LI cut-offs were generated by using X-tile software in the training sets.
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Breast Cancer Research

ISSN: 1465-542X

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