Table 1 Clinicopathologic features of the whole
Characteristics | Whole series | Luminal class | HER2+ class | Triple-negative class | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Training No (%) | Validation No (%) | P | Training No (%) | Validation No (%) | P | Training No (%) | Validation No (%) | P |
Age | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Median (Range) | 54 (18-70) | 55 (18-70) | 55 (28-70) | 0.690 | 52 (29-69) | 52 (27-70) | 0.657 | 49.5 (29-70) | 50 (27-70) | 0.885 |
Menopausal status | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Premenopausal | 571 (39.2) | 116 (36.7) | 232 (35.6) | 0.887 | 31 (47.7) | 58 (45.3) | Â | 44 (54.8) | 90 (56.3) | 0.892 |
Postmenopausal | 886 (60.8) | 200 (63.3) | 419 (64.4) | Â | 34 (52.3) | 70 (57.7) | 0.762 | 36 (45.1) | 70 (34.8) | Â |
Tumor grade | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Grade I | 255 (17.5) | 80 (25.3) | 151 (23.2) | Â | 2 (3.1) | 5 (3.9) | Â | 3 (3.6) | 1 (0.6) | 0.892 |
Grade II | 479 (32.9) | 141 (43.9) | 282 (43.3) | 0.371 | 8 (12.3) | 25 (19.5) | 0.417 | 7 (8.3) | 8 (5.0) | Â |
Grade III | 723 (48.6) | 95 (29.6) | 218 (33.5) | Â | 55 (84.6) | 98 (76.6) | Â | 70 (88.1) | 151 (94.4) | Â |
Tumor size | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   ≤ 2 cm | 899 (61.8) | 215 (68.1) | 433 (66.5) | 0.561 | 40 (61.5) | 77 (60.2) | 0.877 | 42 (52.5) | 71 (44.4) | 0.180 |
   > 2 cm | 556 (38.2) | 101 (31.9) | 218 (33.5) |  | 25 (38.5) | 51 (39.8) |  | 38 (47.5) | 89 (55.6) |  |
Tumor type | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Ductal, no special type | 853 (58.5) | 159 (50.3) | 331 (50.8) | 0.874 | 59 (90.8) | 112 (88.2) | 0.807 | 70 (87.5) | 136 (86.1) | 1.00 |
Other histologic types | 604 (41.5) | 157 (49.7) | 320 (49.2) | Â | 6 (9.2) | 15 (11.8) | Â | 12 (12.5) | 22 (13.9) | Â |
NPI a | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Good | 457 (31.4) | 141 (44.6) | 275 (42.2) | Â | 4 (6.5) | 16 (12.5) | Â | 7 (8.6) | 13 (8.1) | Â |
Moderate | 767 (52.6) | 145 (45.9) | 295 (45.3) | 0.312 | 47 (72.3) | 78 (60.9) | 0.226 | 55 (68.9) | 109 (68.1) | 0.417 |
Poor | 233 (16.0) | 30 (9.5) | 81 (12.4) | Â | 14 (21.5) | 34 (26.6) | Â | 18 (22.5) | 38 (23.8) | Â |
Mean (range) | 3.4 (2.04-5) | 3.42 (2.05-5) | 3.43 (2.06-5) | Â | 4.7 (2.6-5) | 4.7 (2.6-5) | Â | 4.51 (2.05-5) | 4.52 (2.05-5) | Â |
Recurrence | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Local: No | 1,249 (89.0) | 283 (89.6) | 588 (90.3) | Â | 55 (84.6) | 108 (84.4) | Â | 70 (87.5) | 136 (85.0) | 0.564 |
   Yes | 160 (11.0) | 33 (10.4) | 63 (9.7) | 0.819 | 10 (15.4) | 20 (15.6) | 1.000 | 10 (12.5) | 24 (15.0) |  |
Regional: No | 1,280 (91.0) | 291 (92.1) | 594 (91.2) | Â | 58 (89.2) | 112 (87.5) | Â | 70 (87.5) | 147 (91.9) | 0.259 |
   Yes | 129 (9.0) | 25 (7.9) | 57 (8.8) | 0.713 | 7 (10.8) | 16 (12.5) | 0.817 | 10 (12.5) | 13 (8.1) |  |
Distant: No | 1,014 (69.6) | 239 (75.6) | 473 (72.7) | 0.278 | 34 (52.3) | 71 (55.5) | Â | 50 (62.5) | 107 (66.9) | 0.573 |
   Yes | 443 (30.4) | 77 (24.4) | 178 (27.3) |  | 31 (47.7) | 57 (44.5) | 0.760 | 30 (37.5) | 53 (33.1) |  |