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Figure 8 | Breast Cancer Research

Figure 8

From: Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells

Figure 8

Networks of tumor-necrosis factor (TNF)-α-related genes that exhibited alterations in gene expression on selection for resistance to docetaxel in MCF-7 breast carcinoma (a), A2780 ovarian carcinoma (b), or MDA-MB-231 breast carcinoma (c) cells. Gene expressions in the wild-type and docetaxel-resistant cell lines were compared with microarray analysis, after which differentially expressed genes were grouped into functional interaction networks, as described in Materials and methods. Genes upregulated in docetaxel-resistant cells are depicted by using red circles, whereas genes downregulated in docetaxel-resistant cells are depicted by using blue circles. Linker genes are depicted in green diamonds. Direct activating or inhibitory interactions are indicated with the symbols → and , respectively. Indirect interactions involving additional proteins are depicted with dashed lines.

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