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Figure 1 | Breast Cancer Research

Figure 1

From: Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells

Figure 1

Docetaxel or paclitaxel-induced production of soluble tumor-necrosis factor alpha (sTNF-α) in MCF-7 CC and A2780 cells. (a) The mean concentration of sTNF-α (± standard error) (n = 4) found in the medium of MCF-7CC (black) or A2780 (white) cells cultured for 48 hours with varying amounts of docetaxel. (b) The mean concentration of sTNF-α (± standard error) (n = 4) found in the medium of A2780 cells cultured for 48 hours with varying amounts of paclitaxel. (c) The effect of docetaxel (45 nM) and/or the nuclear factor (NF)-κB inhibitor SN-50 (7 μg/ml) on sTNF-α production in A2780 cells. The significance of differences in sTNF-α levels was assessed by using a Student t test; P values of < 0.01 and < 0.001 are represented by ** and *** symbols, respectively.

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Breast Cancer Research

ISSN: 1465-542X

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