TY - JOUR AU - Hernandez, Lorena AU - Magalhaes, Marco AO AU - Coniglio, Salvatore J. AU - Condeelis, John S. AU - Segall, Jeffrey E. PY - 2011 DA - 2011/12/09 TI - Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis JO - Breast Cancer Research SP - R128 VL - 13 IS - 6 AB - CXCL12-CXCR4 signaling has been shown to play a role in breast cancer progression by enhancing tumor growth, angiogenesis, triggering cancer cell invasion in vitro, and guiding cancer cells to their sites of metastasis. However, CXCR7 also binds to CXCL12 and has been recently found to enhance lung and breast primary tumor growth, as well as metastasis formation. Our goal was to dissect the contributions of CXCR4 and CXCR7 to the different steps of metastasis - in vivo invasion, intravasation and metastasis formation. SN - 1465-542X UR - https://doi.org/10.1186/bcr3074 DO - 10.1186/bcr3074 ID - Hernandez2011 ER -