Figure 1

An eight-gene tumor infiltrating lymphocyte (TIL) signature is associated with pathologic complete response (pCR) after neoadjuvant chemotherapy in the EORTC cohort. (a) Heat map displaying gene (y-axis) and case clusters (x-axis). The TIL-high and TIL-low groups with respective rates of pCR are indicated. Colors correspond to z-normalized expression levels. (b) Average expression levels ±SEM of each gene in the three primary centroids. (c) Odds ratios (log_e transformed, ±SEM) for probability of pCR derived from Fisher's exact tests for each gene in the TIL signature. The TIL mean represents average expression levels across all eight genes. High and low gene expression categories were assigned using the upper quartile as the cut-point.