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Figure 3 | Breast Cancer Research

Figure 3

From: Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity

Figure 3

Schematic representation of the regulation of Smad activity in the cell. A variety of different post-translational modifications and protein-protein interactions control the properties of individual Smads or Smad complexes or both and thereby regulate their transcription factor activity and target gene specificity in a stimulus- and cell type-specific manner. For each control mechanism, one example is given [96–100].

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