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Figure 1 | Breast Cancer Research

Figure 1

From: The role and function of cadherins in the mammary gland

Figure 1

Diagram of the different classes of cadherins with distinct characteristics in both the extracellular and cytoplasmic domains. Type 1 cadherins contain extracellular calcium binding domains, including the histidine-alanine-valine (HAV) and tryptophan (W) conserved motifs, along with cytoplasmic domains that bind to β-catenin and p120 and connect the cadherin to the actin cytoskeleton. Type II cadherins have similar motifs, but instead of one tryptophan, they contain two. Type III cadherins do not have a cytoplasmic domain, but rather a glycosylphophatidylinositol (GPI) anchor. Protocadherins and desmosomal cadherins have similar extracellular domains, but their cytoplasmic domains are different. Fat and Daschous cadherins are unique in that the number of extracellular domain repeats can vary in number, and their cytoplasmic domains interact with a different set of cytoplasmic proteins. B-cat, β-catenin; TM, transmembrane.

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