Breast Cancer Research

Table 5 Multivariate survival analyses of ER negative cases for ALDH1A1, ITGA6 and Total CSC score

From: Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance

Variable	Complete case analysis					Multiple imputation (M = 50)
	n	HR (95% CI)	P	T (95% CI)	P	n	HR (95% CI)	P	T (95% CI)	P
Grade	481	3.6 (1.3 to 9.7)	0.011	0.32 (0.16 to 0.61)	0.001	1, 070	3.9 (1.8 to 8.3)	< 0.001	0.42 (0.25 to 0.68)	< 0.001
Node status		4.1 (2.6 to 6.3)	< 0.001	NA			2.8 (2.1 to 3.9)	< 0.001	NA
Tumour size		*		NA			1.5 (1.1 to 1.9)	0.002	NA
PR +		0.25 (0.13 to 0.50)	< 0.001	NA			0.16 (0.03 to 0.69)	0.015	2.1 (0.78 to 5.4)	0.146
HER2+		*		NA			1.4 (0.99 to 2.0)	0.060	NA
ALDH1A1 +		2.3 (1.3 to 4.0)	0.004	NA			1.4 (0.83 to 2.5)	0.191	NA
Grade	401	3.0 (0.99 to 9.0)	0.052	0.39 (0.18 to 0.82)	0.013	1, 070	4.2 (2.0 to 8.9)	< 0.001	0.40 (0.24 to 0.64)	< 0.001
Node status		4.2 (2.6 to 6.7)	< 0.001	NA			2.9 (2.1 to 4.0)	< 0.001	NA
Tumour size		*		NA			1.5 (1.1 to 1.9)	0.003	NA
PR +		0.23 (0.11 to 0.49)	< 0.001	NA			0.42 (0.26 to 0.69)	0.001	NA
HER2+		*		NA			1.4 (1.0 to 2.0)	0.034	NA
ITGA6 +		7.5 (2.6 to 21.6)	< 0.001	0.18 (0.06 to 0.54)	0.002		2.8 (1.2 to 6.3)	0.013	0.50 (0.24 to 1.0)	0.055
Grade	298	3.8 (1.1 to 13.0)	0.036	0.30 (0.13 to 0.68)	0.004	1, 070	4.0 (1.8 to 8.5)	< 0.001	0.41 (0.25 to 0.67)	< 0.001
Node status		4.2 (2.4 to 7.4)	< 0.001	NA			2.9 (2.1 to 4.0)	< 0.001	NA
Tumour size		*		NA			1.5 (1.1 to 1.9)	0.003	NA
PR +		0.15 (0.05 to 0.44)	< 0.001	NA			0.43 (0.26 to 0.70)	0.001	NA
HER2 +		*		NA			1.4 (1.0 to 2.0)	0.037	NA
Endocrine therapy		1.7 (0.98 to 2.9)	0.057	NA			*		NA
Total CSCs (0-3)		1.7 (1.3 to 2.4)	< 0.001	NA			1.8 (1.2 to 2.6)	0.002	0.71 (0.51 to 0.99)	0.042

*Covariate dropped from final model. Grade, tumour size and Total CSCs modelled as continuous variables.

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