Table 3 CSC marker associations with clinical characteristics
From: Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance
| Â | Â | ER POSITIVE | ER NEGATIVE | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variable | Â | CD44+CD24-/low | ALDH1A1 | ALDH1A3 | ITGA6 | CD44+CD24-/low | ALDH1A1 | ALDH1A3 | ITGA6 | ||||||||
| Â | Â | Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive |
Morphology | Ductal | 1, 030 (73) | 241 (81) | 1, 357 (73) | 38 (83) | 1, 242 (73) | 52 (75) | 1, 116 (74) | 41 (71) | 369 (88) | 125 (83) | 491 (85) | 45 (90) | 434 (85) | 60 (90) | 373 (86) | 83 (85) |
| Â | Lobular | 246 (17) | 34 (11) | 315 (17) | 3 (7) | 277 (16) | 11 (16) | 241 (16) | 11 (19) | 20 (5) | 6 (4) | 32 (5) | 0 (0) | 25 (5) | 3 (4) | 23 (5) | 4 (4) |
| Â | Other | 140 (10) | 23 (8) | 188 (10) | 5 (11) | 176 (10) | 6 (9) | 142 (9) | 6 (10) | 32 (8) | 19 (13) | 58 (10) | 5 (10) | 52 (10) | 4 (6) | 37 (9) | 11 (11) |
| Â | P-value | 0.012 | 0.172 | 0.892 | 0.803 | 0.169 | 0.238* | 0.625* | 0.645* | ||||||||
Grade | 1 | 283 (23) | 78 (33) | 402 (25) | 3 (11) | 356 (25) | 10 (19) | 304 (24) | 10 (26) | 23 (6) | 1 (1) | 32 (6) | 0 (0) | 29 (7) | 1 (2) | 22 (6) | 2 (3) |
| Â | 2 | 684 (56) | 112 (47) | 873 (55) | 13 (46) | 787 (55) | 28 (53) | 700 (55) | 20 (51) | 103 (28) | 28 (23) | 145 (29) | 7 (21) | 119 (27) | 11 (24) | 109 (29) | 15 (19) |
| Â | 3 | 251 (21) | 49 (21) | 315 (20) | 12 (43) | 297 (21) | 15 (28) | 260 (21) | 9 (23) | 242 (66) | 93 (76) | 321 (64) | 27 (79) | 295 (67) | 33 (73) | 242 (65) | 60 (78) |
| Â | P-value | 0.006 | 0.012* | 0.335 | 0.874 | 0.012* | 0.164* | 0.538* | 0.086* | ||||||||
Node status | Negative | 783 (60) | 184 (68) | 1064 (61) | 23 (53) | 972 (62) | 41 (63) | 859 (62) | 34 (63) | 203 (51) | 84 (64) | 310 (57) | 19 (41) | 268 (56) | 34 (54) | 206 (52) | 55 (62) |
| Â | Positive | 533 (40) | 86 (32) | 669 (39) | 20 (47) | 602 (38) | 24 (37) | 528 (38) | 20 (37) | 195 (49) | 48 (36) | 231 (43) | 27 (59) | 207 (44) | 29 (46) | 194 (48) | 34 (38) |
| Â | P-value | 0.008 | 0.293 | 0.830 | 0.878 | 0.012 | 0.036 | 0.712 | 0.078 | ||||||||
Tumour size | < 2 cm | 788 (58) | 182 (64) | 1050 (59) | 22 (49) | 964 (59) | 37 (55) | 842 (59) | 30 (52) | 176 (44) | 61 (43) | 236 (43) | 23 (48) | 208 (43) | 23 (37) | 167 (41) | 38 (44) |
| Â | 2 to 4.9 cm | 545 (40) | 88 (31) | 695 (39) | 22 (49) | 628 (38) | 28 (42) | 551 (38) | 27 (47) | 208 (52) | 74 (52) | 289 (53) | 23 (48) | 259 (54) | 36 (58) | 225 (55) | 45 (52) |
|  | ≥5 cm | 33 (2) | 13 (5) | 50 (3) | 1 (2) | 44 (3) | 2 (3) | 44 (3) | 1 (2) | 14 (4) | 6 (4) | 24 (4) | 2 (4) | 16 (3) | 3 (5) | 20 (5) | 3 (3) |
| Â | P-value | 0.005 | 0.362* | 0.747* | 0.469* | 0.916 | 0.777* | 0.519* | 0.821* | ||||||||