Skip to main content

Table 3 Risk of contralateral breast cancer associated with single-nucleotide polymorphism genotypes according to estrogen receptor status

From: Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study

  

ER-positivea

ER-negativea

 

SNPb/Gene region

Genotype

Cases (CBC)

Controls (UBC)

RRc (95% CI)

Cases (CBC)

Controls (UBC)

RRc (95% CI)

Pvalued

rs2981582/FGFR2

GG

96

232

1.0

64

124

1.0

 
 

AG

167

347

1.3 (0.9-1.9)

100

165

1.3 (0.8-2.0)

0.99

 

AA

73

161

1.6 (1.0-2.3)

28

49

1.3 (0.7-2.3)

 

rs1219648/FGFR2

AA

81

221

1.0

58

119

1.0

 
 

AG

174

354

1.4 (1.0-2.0)

102

169

1.4 (0.9-2.2)

0.74

 

GG

80

164

1.7 (1.1-2.6)

33

50

1.5 (0.8-2.8)

 

rs3803662/TOX3

CC

138

331

1.0

89

156

1.0

 
 

CT

150

335

1.2 (0.9-1.7)

81

137

1.1 (0.7-1.7)

0.26

 

TT

47

75

1.8 (1.1-2.9)

23

43

0.9 (0.5-1.7)

 

rs13281615/8q24

AA

97

222

1.0

51

100

1.0

 
 

AG

158

378

1.1 (0.8-1.5)

103

175

1.3 (0.8-2.1)

0.78

 

GG

82

141

1.4 (0.9-2.1)

38

62

1.2 (0.6-2.2)

 

rs13387042/2q35

GG

83

169

1.0

31

85

1.0

 
 

AG

141

347

0.8 (0.6-1.2)

105

177

1.8 (1.1-3.1)

0.0008

 

AA

112

224

0.9 (0.6-1.3)

57

73

3.1 (1.7-5.7)

 

rs11235127/TMEM135

GG

212

538

1.0

138

218

1.0

 
 

AG

108

180

1.5 (1.1-2.1)

46

106

0.8 (0.5-1.2)

0.01

 

AA

17

22

2.5 (1.2-5.3)

9

12

1.0 (0.3-3.0)

 

rs7313833/PTHLH

GG

116

337

1.0

92

155

1.0

 
 

AG

168

326

1.5 (1.1-2.0)

76

147

0.9 (0.6-1.4)

0.30

 

AA

52

71

2.0 (1.2-3.3)

25

32

1.4 (0.7-2.8)

 

rs7696175/4p14

GG

145

246

1.0

63

111

1.0

 
 

AG

141

357

0.8 (0.6-1.0)

97

169

1.0 (0.6-1.6)

0.39

 

AA

51

135

0.7 (0.4-1.0)

33

55

1.0 (0.5-1.8)

 
  1. aEstrogen receptor (ER) status of the first primary tumor. bSingle-nucleotide polymorphisms (SNPs) that had a main effect on contralateral breast cancer (CBC) risk with a P value of less than 0.1 were selected for ER status interaction analysis. cRate ratio (RR) adjusted for age at diagnosis of first primary tumor and weighting factor that accounts for the counter-matched design. dOne degree of freedom interaction P value. CI, confidence interval; UBC, unilateral breast cancer.
Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us