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Table 1 Effects of forced expression of ARTEMIN (ARTN) in estrogen receptor (ER) negative mammary carcinoma (ER-MC) cells on expression of genes functionally involved in epithelial-mesenchymal transition (EMT) and metastatic progression

From: ARTEMIN synergizes with TWIST1 to promote metastasis and poor survival outcome in patients with ER negative mammary carcinoma

  

BT549

 

MDA-MB-231

 

Gene Function

Gene

Fold change

p-value

Fold change

p-value

Epithelial

CTNNB1

0.48

1.60E-03

0.47

1.25E-03

 

CTNNA1

1.3

8.71E-03

0.68

5.80E-04

 

CTNNG

0.52

8.23E-03

0.46

1.58E-02

 

OCLN

0.35

9.71E-04

0.94

2.07E-02

 

CDH1

0.12

4.93E-02

0.21

4.94E-03

Mesenchymal

SNAI2

1.68

6.26E-03

1.1

1.67E-02

 

VIM

2.44

9.39E-04

1.23

6.79E-03

 

TWIST1

5.49

3.98E-03

4.56

3.99E-03

 

SPARC

1.82

2.03E-02

2.35

6.39E-03

Metastatic

NME1

2.7

1.57E-02

1.09

1.53E-03

 

PLAU

1.02

4.40E-04

0.85

1.57E-03

 

MMP9

2.11

3.64E-02

0.49

1.44E-03

 

MET

0.85

1.70E-02

0.76

3.10E-03

 

MMP2

1.04

2.07E-02

4.17

1.54E-03

 

MTA2

3.02

8.75E-03

1.58

1.49E-02

 

MMP1

1.29

4.36E-03

0.58

2.18E-02

 

NFKB1A

2.23

7.19E-03

1.02

3.49E-03

 

NFKB1

2.77

1.73E-02

1.7

3.96E-03

 

ERBB2

1.24

1.71E-03

0.96

5.05E-03

 

MYC

3.55

3.97E-04

0.95

1.40E-03

  1. Results are represented as the fold change in messenger RNA (mRNA) levels in BT549-ARTN or MDA-MB-231-ARTN cells relative to the respective VEC cells. Values less than one indicates decreased expression and more than one indicates increased expression of the specific mRNA.