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Table 1 Number of mutation carriers by country grouping affection status and tumour marker characteristics

From: Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Country Group

BRCA1

BRCA2

Unaffected

Breast Cancer

ER-

ER+

PR-

PR+

Austria1

465

179

318

326

76

51

76

44

Australia2

660

552

541

671

235

200

297

121

Canada3

443

358

386

415

107

70

89

68

Denmark4

507

319

463

363

98

93

79

45

France-Belgium-Spain5

1,673

1,256

1,217

1,712

140

165

1,661

127

Finland6

103

105

91

117

59

54

74

39

Germany7

1,231

589

648

1,172

443

336

457

311

Iceland8

0

135

24

111

21

57

18

57

Italy9

994

666

686

974

203

251

231

216

Latvia-Lithuania-Russia10

190

0

79

111

21

6

18

7

Sweden11

537

177

396

318

86

54

89

50

Netherlands12

804

319

611

512

72

41

69

29

UK-Eire13

1,107

866

1,008

965

268

239

175

104

USA14

2,707

1559

2,118

2048

482

366

512

297

Total

11,421

7,080

8,686

9,815

2,311

1,983

2,345

1,515

  1. Studies in country groups:1:MUV; 2:BCFR/KCONFAB; 3:OCGN/BCFR/INHERIT; 4:CBCS/OUH; 5: GEMO/CNIO/HCSC/ICO/MOD-SQUAD; 6:HEBCS; 7:GC-HBOC/DKFZ; 8:ILUH; 9:CONSIT-TEAM/IOVHBOCS/PBCS; 10: NNPIO/BFBOCC; 11: SWE-BRCA; 12: HEBON; 13:EMBRACE/UKGRFOCR; 14:FCCC/GEMO/GEORGETOWN/MAGIC/MAYO/MSKCC/NCI/OSU-CCG/UCI/UCSF/UKGRFOCR/UPENN/WCRI