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Table 1 Number of mutation carriers by country grouping affection status and tumour marker characteristics

From: Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Country Group BRCA1 BRCA2 Unaffected Breast Cancer ER- ER+ PR- PR+
Austria1 465 179 318 326 76 51 76 44
Australia2 660 552 541 671 235 200 297 121
Canada3 443 358 386 415 107 70 89 68
Denmark4 507 319 463 363 98 93 79 45
France-Belgium-Spain5 1,673 1,256 1,217 1,712 140 165 1,661 127
Finland6 103 105 91 117 59 54 74 39
Germany7 1,231 589 648 1,172 443 336 457 311
Iceland8 0 135 24 111 21 57 18 57
Italy9 994 666 686 974 203 251 231 216
Latvia-Lithuania-Russia10 190 0 79 111 21 6 18 7
Sweden11 537 177 396 318 86 54 89 50
Netherlands12 804 319 611 512 72 41 69 29
UK-Eire13 1,107 866 1,008 965 268 239 175 104
USA14 2,707 1559 2,118 2048 482 366 512 297
Total 11,421 7,080 8,686 9,815 2,311 1,983 2,345 1,515
  1. Studies in country groups:1:MUV; 2:BCFR/KCONFAB; 3:OCGN/BCFR/INHERIT; 4:CBCS/OUH; 5: GEMO/CNIO/HCSC/ICO/MOD-SQUAD; 6:HEBCS; 7:GC-HBOC/DKFZ; 8:ILUH; 9:CONSIT-TEAM/IOVHBOCS/PBCS; 10: NNPIO/BFBOCC; 11: SWE-BRCA; 12: HEBON; 13:EMBRACE/UKGRFOCR; 14:FCCC/GEMO/GEORGETOWN/MAGIC/MAYO/MSKCC/NCI/OSU-CCG/UCI/UCSF/UKGRFOCR/UPENN/WCRI