Table 3 Multivariate analyses of 34 antibodies for interaction with chemotherapy arm

AF6

Neg.

99/94

0.94 (0.50 to 1.79)

0.663

Pos.

321/335

0.86 (0.61 to 1.23)

Angiogenin

Neg.

34/37

1.68 (0.47 to 5.96)

0.1

Pos.

439/440

0.66 (0.49 to 0.89)

Aurora A

Neg.

293/292

0.91 (0.62 to 1.33)

0.228

Pos.

135/141

0.61 (0.38 to 1.00)

BCL2

Neg.

184/193

0.78 (0.52 to 1.17)

0.905

Pos.

285/295

0.80 (0.54 to 1.19)

α-Catenin

Neg.

177/182

0.85 (0.53 to 1.37)

0.875

Pos.

250/251

0.79 (0.53 to 1.16)

β-Catenin

Neg.

123/142

1.19 (0.69 to 2.05)

0.14

Pos.

324/312

0.67 (0.47 to 0.96)

CAV1

Neg.

82/97

1.11 (0.50 to 2.44)

0.229

Pos.

389/389

0.69 (0.51 to 0.94)

CD10

Neg.

197/212

0.87 (0.55 to 1.38)

0.741

Pos.

259/249

0.77 (0.54 to 1.12)

CD44

Neg.

210/220

0.63 (0.41 to 0.96)

0.158

Pos.

128/152

1.03 (0.61 to 1.73)

CK5/6

Neg.

122/126

0.84 (0.48 to 1.48)

0.96

Pos.

332/335

0.79 (0.56 to 1.10)

CK8/18

Neg.

13/9

4.73 (0.96 to 23.3)

0.446

Pos.

468/480

0.69 (0.52 to 0.91)

CK14

Neg.

386/388

0.77 (0.56 to 1.05)

0.142

Pos.

84/74

0.41 (0.18 to 0.90)

Cyclin D1

Neg.

161/155

0.78 (0.48 to 1.26)

0.974

Pos.

317/331

0.78 (0.55 to 1.10)

E-Cadherin

Neg.

62/66

1.77 (0.69 to 4.59)

0.154

Pos.

432/441

0.71 (0.53 to 0.95)

EGFR

Neg.

401/413

0.85 (0.63 to 1.16)

0.235

Pos.

95/90

0.58 (0.30 to 1.13)

ER

Neg.

137/146

0.79 (0.52 to 1.22)

0.976

Pos.

394/391

0.79 (0.56 to 1.10)

FGFR1

Neg.

56/58

0.32 (0.10 to 1.02)

0.178

Pos.

306/320

0.84 (0.59 to 1.19)

FHIT

Neg.

127/110

0.00 (0.52 to 1.90)

0.473

Pos.

321/351

0.73 (0.52 to 1.01)

GATA3

Neg.

88/78

0.74 (0.40 to 1.37)

0.908

Pos.

407/409

0.74 (0.54 to 1.02)

HER2

Neg.

451/466

0.85 (0.63 to 1.15)

0.367

Pos.

93/82

0.65 (0.36 to 1.17)

Ki67

Neg.

327/334

1.10 (0.75 to 1.61)

0.012

Pos.

147/133

0.51 (0.33 to 0.79)

MET

Neg.

301/301

0.91 (0.63 to 1.30)

0.154

Pos.

150/165

0.59 (0.38 to 0.94)

Moesin

Neg.

412/412

0.77 (0.57 to 1.05)

0.92

Pos.

56/62

0.80 (0.39 to 1.65)

MUC1

Neg.

53/42

0.73 (0.32 to 1.70)

0.651

Pos.

461/477

0.73 (0.55 to 0.98)

P21

Neg.

187/191

0.74 (0.48 to 1.14)

0.879

Pos.

272/273

0.76 (0.51 to 1.13)

P27

Neg.

78/97

0.76 (0.41 to 1.42)

0.826

Pos.

378/390

0.73 (0.53 to 1.00)

P53

Neg.

364/382

0.76 (0.54 to 1.08)

0.74

Pos.

123/123

0.71 (0.45 to 1.13)

P-Cadherin

Neg.

282/288

0.78 (0.52 to 1.17)

0.622

Pos.

179/192

0.68 (0.46 to 1.02)

PR

Neg.

255/233

0.86 (0.61 to 1.22)

0.601

Pos.

276/305

0.76 (0.50 to 1.15)

PTEN

Neg.

152/162

0.99 (0.60 to 1.64)

0.221

Pos.

315/295

0.68 (0.47 to 0.97)

TACC2

Neg.

70/78

0.54 (0.25 to 1.20)

0.397

Pos.

366/357

0.87 (0.63 to 1.19)

TACC3

Neg.

13/22

0.29 (0.04 to 2.14)

0.363

Pos.

284/280

0.97 (0.67 to 1.41)

TAU

Neg.

340/345

0.83 (0.59 to 1.16)

0.611

Pos.

65/76

0.96 (0.38 to 2.42)

TOPO2A

Neg.

104/95

0.82 (0.39 to 1.74)

0.917

Pos.

359/355

0.77 (0.56 to 1.06)