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Table 1 Sample characteristics

From: Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness

 

Training set

Test set

Extra Validation set

 

n (%)

n (%)

n (%)

Total

84

100%

72

100%

69

100%

Patient series

      

Clinical genetics centre

34

40%

18

25%

  

Neoadjuvant series

50

60%

8

11%

  

Randomised controlled trial series

0

0%

46

64%

  

Subtype

      

HER2+

11

13%

5

7%

0

0%

ER+HER2-

22

26%

10

14%

0

0%

Triple-negative (TN)

52

61%

57

79%

69

100%

ER expression

      

Negative

57

67%

59

82%

69

100%

Positive

28

33%

13

18%

0

0%

BRCA1 mutation

      

BRCA1 mutation

16

19%

17

24%

7

10%

No mutation

19

23%

44

61%

0

0%

Unknown

49

58%

11

15%

62

90%

BRCA1like status aCGH

      

BRCA1-like

37

44%

40

56%

50

72%

Sporadic-like

47

56%

32

44%

19

28%

  1. aCGH, array Comparative Genomic Hybridisation.