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Figure 7 | Breast Cancer Research

Figure 7

From: Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts

Figure 7

NRC-03 and NRC-07 halt the growth of breast cancer xenografts in mice. MDA-MB-231 breast cancer cells were implanted in the right hind flank of NOD SCID mice. Once tumors reached a volume at least 120 mm3, they were injected with the HBSS alone or with 0.5 mg NRC-03 or NRC-07 (in HBSS) on days 1, 3, and 5. (a) Tumor volume was determined on days 1, 3, 5, 7, 9, 11, and 12 after the start of peptide treatment. Data shown are the mean tumor volume ± SEM from three independent experiments (three mice per group conducted three times for a total of nine mice per treatment). Statistical significance was determined with the Bonferroni multiple comparisons test; *p < 0.05 compared with HBSS-treated animals. (b) On day 12, mice were killed and photographed, and (c) the tumors were excised and photographed (d). Tumor sections were stained with hematoxylin and eosin, and photographed by using bright-field microscopy (×400). Scale bars indicate 400 μm. T, viable cells; N, necrotic cells. Representative images are shown.

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