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Table 4 Odds ratios for breast cancer according to quintiles of different postmenopausal mammographic characteristics among 960 cases and 1,662 controls

From: Nondense mammographic area and risk of breast cancer

  Odds Ratios and 95% Confidence Intervals
Mammographic characteristics Cases Controls Model 11 Model 22 Model 33
Absolute dense area, quintiles         
1 117 333 1.00   1.00   1.00  
2 167 332 1.42 (1.08-1.89) 1.44 (1.08-1.92) 1.39 (1.04-1.86)
3 167 333 1.43 (1.08-1.89) 1.44 (1.08-1.92) 1.42 (1.06-1.90)
4 240 332 2.07 (1.58-2.71) 1.99 (1.50-2.62) 2.04 (1.53-2.70)
5 269 332 2.40 (1.83-3.13) 2.19 (1.65-2.89) 2.30 (1.74-3.06)
Absolute non-dense area, quintiles         
1 271 333 1.00   1.00   1.00  
2 177 332 0.66 (0.52-0.84) 0.60 (0.47-0.78) 0.62 (0.47-0.80)
3 186 333 0.70 (0.55-0.89) 0.63 (0.48-0.82) 0.62 (0.48-0.82)
4 178 332 0.68 (0.53-0.86) 0.58 (0.44-0.76) 0.55 (0.41-0.72)
5 148 332 0.56 (0.44-0.73) 0.46 (0.34-0.62) 0.41 (0.30-0.56)
Percent dense area, quintiles         
1 109 334 1.00   1.00   N/A  
2 161 331 1.49 (1.12-1.98) 1.56 (1.16-2.10)   
3 153 333 1.42 (1.06-1.89) 1.57 (1.16-2.13)   
4 231 332 2.13 (1.62-2.81) 2.44 (1.81-3.30)   
5 306 332 2.83 (2.17-3.71) 3.28 (2.41-4.45)   
  1. 1) Adjusted for age at mammography (continuous), study (Nurses' Health Study, Nurses' Health Study II).
  2. 2) Adjusted for age at mammography (continuous), study (Nurses' Health Study, Nurses' Health Study II), age at menarche (< 12, 12-13, ≥ 14), family history of breast cancer (yes, no), parity + age at first birth (nulliparous, < 3 children age < 26, < 3 children age ≥ 26, ≥ 3 children age < 26, ≥ 3 children age ≥ 26), body mass index (< 20, 20-< 22.5, 22.5-< 25, 25-< 27.5, 27.5-< 30, 30-< 32.5, 32.5-< 35, ≥ 35 kg/m2), alcohol use (0, < 5, 5-< 15, ≥ 15 g/day, unknown), age at menopause (continuous), and current hormonal therapy (yes, no, unknown).
  3. 3) Adjusted for covariates in model 2, plus absolute non-dense or absolute dense area (quintiles), as appropriate.