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Table 4 Odds ratios for breast cancer according to quintiles of different postmenopausal mammographic characteristics among 960 cases and 1,662 controls

From: Nondense mammographic area and risk of breast cancer

 

Odds Ratios and 95% Confidence Intervals

Mammographic characteristics

Cases

Controls

Model 11

Model 22

Model 33

Absolute dense area, quintiles

        

1

117

333

1.00

 

1.00

 

1.00

 

2

167

332

1.42

(1.08-1.89)

1.44

(1.08-1.92)

1.39

(1.04-1.86)

3

167

333

1.43

(1.08-1.89)

1.44

(1.08-1.92)

1.42

(1.06-1.90)

4

240

332

2.07

(1.58-2.71)

1.99

(1.50-2.62)

2.04

(1.53-2.70)

5

269

332

2.40

(1.83-3.13)

2.19

(1.65-2.89)

2.30

(1.74-3.06)

Absolute non-dense area, quintiles

        

1

271

333

1.00

 

1.00

 

1.00

 

2

177

332

0.66

(0.52-0.84)

0.60

(0.47-0.78)

0.62

(0.47-0.80)

3

186

333

0.70

(0.55-0.89)

0.63

(0.48-0.82)

0.62

(0.48-0.82)

4

178

332

0.68

(0.53-0.86)

0.58

(0.44-0.76)

0.55

(0.41-0.72)

5

148

332

0.56

(0.44-0.73)

0.46

(0.34-0.62)

0.41

(0.30-0.56)

Percent dense area, quintiles

        

1

109

334

1.00

 

1.00

 

N/A

 

2

161

331

1.49

(1.12-1.98)

1.56

(1.16-2.10)

  

3

153

333

1.42

(1.06-1.89)

1.57

(1.16-2.13)

  

4

231

332

2.13

(1.62-2.81)

2.44

(1.81-3.30)

  

5

306

332

2.83

(2.17-3.71)

3.28

(2.41-4.45)

  
  1. 1) Adjusted for age at mammography (continuous), study (Nurses' Health Study, Nurses' Health Study II).
  2. 2) Adjusted for age at mammography (continuous), study (Nurses' Health Study, Nurses' Health Study II), age at menarche (< 12, 12-13, ≥ 14), family history of breast cancer (yes, no), parity + age at first birth (nulliparous, < 3 children age < 26, < 3 children age ≥ 26, ≥ 3 children age < 26, ≥ 3 children age ≥ 26), body mass index (< 20, 20-< 22.5, 22.5-< 25, 25-< 27.5, 27.5-< 30, 30-< 32.5, 32.5-< 35, ≥ 35 kg/m2), alcohol use (0, < 5, 5-< 15, ≥ 15 g/day, unknown), age at menopause (continuous), and current hormonal therapy (yes, no, unknown).
  3. 3) Adjusted for covariates in model 2, plus absolute non-dense or absolute dense area (quintiles), as appropriate.