Nondense mammographic area and risk of breast cancer

Breast Cancer Research

Table 3 Odds ratios for breast cancer according to tertiles of different premenopausal mammographic characteristics among 464 cases and 998 controls

	Odds Ratios and 95% Confidence Intervals
Mammographic characteristics	Cases	Controls	Model 1¹		Model 2²		Model 3³
Absolute dense area, tertiles
1	113	330	1.00		1.00		1.00
2	156	339	1.43	(1.07-1.92)	1.40	(1.04-1.88)	1.39	(1.03-1.87)
3	195	329	2.07	(1.52-2.84)	2.01	(1.45-2.77)	2.05	(1.48-2.84)
Absolute non-dense area, tertiles
1	192	330	1.00		1.00		1.00
2	153	339	0.77	(0.59-1.01)	0.72	(0.54-0.95)	0.69	(0.52-0.92)
3	119	329	0.62	(0.47-0.83)	0.51	(0.36-0.72)	0.50	(0.35-0.71)
Percent dense area, tertiles
1	95	330	1.00		1.00		N/A
2	167	339	1.75	(1.30-2.36)	1.95	(1.41-2.69)
3	202	329	2.18	(1.62-2.92)	2.72	(1.93-3.83)

¹⁾ Adjusted for age at mammography (continuous), study (Nurses' Health Study, Nurses' Health Study II).
²⁾ Adjusted for age at mammography (continuous), study (Nurses' Health Study, Nurses' Health Study II), age at menarche (< 12, 12-13, ≥ 14), family history of breast cancer (yes, no), parity + age at first birth (nulliparous, < 3 children age < 26, < 3 children age ≥ 26, ≥ 3 children age < 26, ≥ 3 children age ≥ 26), body mass index (< 20, 20-< 22.5, 22.5-< 25, 25-< 27.5, 27.5-< 30, 30-< 32.5, 32.5-< 35, ≥ 35 kg/m²), and alcohol use (0, < 5, 5-< 15, ≥ 15 g/day, unknown).
³⁾ Adjusted for covariates in model 2, plus absolute non-dense or absolute dense area (tertiles), as appropriate.

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