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Table 5 Cox proportional hazards model for breast cancer-specific mortality

From: Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer

 

Hazard ratio (95% CI)

Pvalue

Multivariate without BCI

  

   Age, ≥ 50 versus < 50

2.34 (0.90-6.13)

0.082

   Tumor size, ≥ 2 cm versus < 2 cm

1.36 (0.61-3.02)

0.451

   Tumor grade, reference grade 1

 

0.008

Grade 2

8.08 (1.07-60.88)

0.043

Grade 3

18.22 (2.33-142.53)

0.006

   Treatmenta

1.09 (0.45-2.61)

0.850

Multivariate with BCI

  

   Age, ≥ 50 versus < 50

2.23 (0.85-5.87)

0.103

   Tumor size, ≥ 2 cm versus < 2 cm

1.28 (0.57-2.87)

0.554

   Tumor grade, reference grade 1

 

0.008

Grade 2

8.67 (1.14-65.73)

0.037

Grade 3

18.95 (2.42-148.48)

0.005

   Treatmenta

0.96 (0.40-2.33)

0.931

   BCIb

9.60 (3.20-28.80)

< 0.0001

Multivariate with only BCI and AO

  

   Adjuvant! Onlinec

1.52 (1.11-2.08)

0.009

   BCIc

3.27 (1.79-5.98)

0.0001

  1. aTamoxifen alone versus tamoxifen plus chemotherapy groups. bHazard ratio calculated for Breast Cancer Index (BCI) relative to an increment of 5 units. cHazard ratio calculated for BCI and Adjuvant! Online (AO) relative to increments of their interquartile range (2.936 for BCI and 5 for AO). CI, confidence interval.