Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer

Table 4 Cox proportional hazards model for all-cause mortality

	Hazard ratio (95% CI)	Pvalue
Multivariate without BCI
Age, ≥ 50 versus < 50	2.77 (1.16-6.58)	0.021
Tumor size, ≥ 2 cm versus < 2 cm	1.24 (0.62-2.48)	0.541
Tumor grade, reference grade 1		0.004
Grade 2	1.96 (0.73-5.21)	0.180
Grade 3	4.81 (1.71-13.57)	0.003
Treatment^a	0.99 (0.46-2.14)	0.981
Multivariate with BCI
Age, ≥ 50 versus < 50	2.62 (1.10-6.28)	0.031
Tumor size, ≥ 2 cm versus < 2 cm	1.13 (0.56-2.27)	0.728
Tumor grade, reference grade 1		0.004
Grade 2	2.02 (0.75-5.38)	0.162
Grade 3	4.86 (1.73-13.66)	0.003
Treatment^a	0.90 (0.42-1.96)	0.796
BCI^b	6.77 (2.80-16.41)	< 0.0001
Multivariate with only BCI and AO
Adjuvant! Online^c	1.45 (1.10-1.91)	0.009
BCI^c	2.82 (1.70-4.67)	< 0.0001

^aTamoxifen alone versus tamoxifen plus chemotherapy groups. ^bHazard ratio calculated for Breast Cancer Index (BCI) relative to an increment of 5 units. ^cHazard ratio calculated for BCI and Adjuvant! Online (AO) relative to increments of their interquartile range (2.936 for BCI and 5 for AO). CI, confidence interval.

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