Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer

Table 3 Cox proportional hazards model for likelihood of distant recurrence

	Hazard ratio (95% CI)	Pvalue
Multivariate without BCI
Age, ≥ 50 versus < 50	1.46 (0.70-3.05)	0.317
Tumor size, ≥ 2 cm versus < 2 cm	1.84 (0.94-3.58)	0.074
Tumor grade, reference grade 1		0.006
Grade 2	3.60 (1.08-12.03)	0.038
Grade 3	7.04 (2.00-24.80)	0.002
Treatment^a	1.13 (0.56-2.28)	0.742
Multivariate with BCI
Age, ≥ 50 versus < 50	1.34 (0.64-2.82)	0.444
Tumor size, ≥ 2 cm versus < 2 cm	1.69 (0.87-3.28)	0.124
Tumor grade, reference grade 1		0.009
Grade 2	3.73 (1.11-12.54)	0.033
Grade 3	6.77 (1.92-23.81)	0.003
Treatment^a	0.99 (0.49-2.03)	0.985
BCI^b	5.32 (2.18-13.01)	0.0002
Multivariate with only BCI and AO
Adjuvant! Online^c	1.42 (1.16-1.74)	0.0007
BCI^c	2.47 (1.50-4.07)	0.0004

^aTamoxifen alone versus tamoxifen plus chemotherapy groups. ^bHazard ratio calculated for Breast Cancer Index (BCI) relative to an increment of 5 units. ^cHazard ratio calculated for BCI and Adjuvant! Online (AO) relative to increments of their interquartile range (2.936 for BCI and 5 for AO). CI, confidence interval.

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