Figure 1

Time-dependent receiver operating characteristic curve analysis of Adjuvant! Online (AO) and AO with Breast Cancer Index (BCI). Linear predictors are derived from a Cox model with AO only (red circles) and from a model with AO and BCI (blue plus) for (a) all subjects and for (b) subjects treated with tamoxifen (Tam) alone. Curves plot the area under the curve (AUC) over time and compare the accuracy of the model score to distinguish patients who will develop a distant metastasis from those who will not. The separation of the curves demonstrates the gain in predictive accuracy of including BCI in the model.