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Figure 1 | Breast Cancer Research

Figure 1

From: Breast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticity

Figure 1

Functional consequences of a type III epithelial-to-mesenchymal transition. An oncogenic epithelial-to-mesenchymal transition (EMT) in a breast carcinoma cell gives rise to a tumor cell with mesenchymal-like features. This transition can lead to the acquisition of a number of pro-metastatic features, including increased motility, invasiveness, anoikis resistance and evasion of the immune system. Recently, the acquisition of cancer stem cell-like properties has been added to this list (that is, self-renewal, multipotency, therapeutic resistance), resulting in significant cross-talk between the EMT and cancer stem cell fields.

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