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Table 3 Expression of MDR-related gene mRNA species in nomegestrol-pretreated MCF7/ADR cells

From: Reversal effects of nomegestrol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line

Comparison

Duration of treatment (days)

MDR1

GSTÏ€

MRP

TopoIIα

MA

0

1.7 ± 0.61

2.0 ± 0.82

0.9 ± 0.30

0.4 ± 0.10

 

2

0.5 ± 0.22*

0.5 ± 0.24**

0.7 ± 0.19

0.4 ± 0.15

 

3

0.1 ± 0.04**

0.5 ± 0.15**

0.7 ± 0.34

0.5 ± 0.21

 

5

0.5 ± 0.21*

0.7 ± 0.30*

0.8 ± 0.17

0.5 ± 0.18

 

10

1.5 ± 0.60

0.9 ± 0.80*

0.7 ± 0.25

0.4 ± 0.09

MW

0

-

-

0.6 ± 0.24

0.8 ± 0.31

 

2

-

-

0.7 ± 0.27

0.8 ± 0.38

 

3

-

-

0.5 ± 0.30

0.7 ± 0.19

 

5

-

-

0.7 ± 0.31

0.7 ± 0.32

 

10

-

-

0.6 ± 0.18

0.7 ± 0.26

  1. Values are ratios of β-actin to MDR-related genes: MA, MCF7/ADR; MW, MCF7/WT. Statistical significance compared with control: *, P <0.05; **, P < 0.01. Data are means ± standard deviation from three experiments. GSTπ, glutathione S-transferase Pi; MDR, multidrug resistance; MRP, MDR-related protein; TopoIIα, topoisomerase IIα.