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Figure 1 | Breast Cancer Research

Figure 1

From: erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines

Figure 1

Western blot analysis. (a) Phosphorylated and total epidermal growth factor receptor (EGFR), erbB2, erbB3, Akt and extracellular-signal regulated kinase 1/2 (ERK1/2) and (b) phosphorylated and total insulin receptor substrate 1 (IRS-1) protein expression following treatment of MCF-7, T47D and BT-474 breast cancer cells with either heregulin β1 (HRGβ1) (10 ng/ml) or vehicle control for 5 minutes. (c) Western blot analysis of phosphorylated and total insulin-like growth factor type I receptor (IGF-IR) protein expression following treatment of MCF-7, T47D and BT-474 breast cancer cells with HRGβ1 (10 ng/ml), IGF-I (10 ng/ml) or vehicle control for 5 minutes. Data are representative of three separate experiments.

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