Reduced homing of CX
CR1-expressing cancer cells in the bone of FKN-null mice. The number of MDA-231 cells detected in the skeleton of transgenic FKN(-/-) mice (n = 5) 24 hours after intra-cardiac inoculation is significantly decreased compared to the number of cells detected in wild-type C56BI/6 mice (n = 4). The number of cells detected in the femora and tibiae per animal is shown as mean + S.E.M. (**-P = 0.0002).