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Table 3 Overlap between the 188 CHEK2 1100delC-associated genes and eight previously published gene-expression signatures

From: Breast tumors from CHEK2 1100delC- mutation carriers: genomic landscape and clinical implications

Gene-expression signature Genes Overlap Proportion
SSP2003 [2] 500 5 0.010
SSP2006 [1] 306 2 0.007
PAM50 [5] 50 1 0.020
70 gene poor-prognosis signature [3] 70 0 0.000
76 gene metastasis signature [4] 76 0 0.000
Gene-expression grade index [6] 128 1 0.008
Recurrence score [7] 21 0 0.000
Recurrence predictor in tamoxifen-treated patients [8] 181 2 0.011
GO: proliferation [49, 50] 1677 13 0.008
  1. The first column contains names and references for the gene-expression signatures as well as the reference for proliferation-associated genes in the Gene Ontology database (GO). The second to fourth columns indicate the number of genes included in the signature, the number overlapping with each signature, and the 188 genes and proportion of genes of each signature among the 188 genes, respectively.