Breast tumors from CHEK2 1100delC- mutation carriers: genomic landscape and clinical implications

Breast Cancer Research

Table 1 Chromosomal regions with differing copy number between CHEK2 1100delC-mutation carriers and others

Chromosome	Start	End	Clones	Sum of clones	Length	Cytoband	P value
1	63762320	75867880	109	410	46865220	1p13.3-31.3	0.0031
1	76025260	87854764	110				0.0004
1	87964559	98030482	81				0.0001
1	98201778	110627540	110				0.0004
8	3329536	5083904	26	46	4279506	8p21.1-2	0.0062
8	5292190	6859255	15				0.0027
8	7041464	7609042	5				0.0066
8	24208215	29092984	35	41	5366218	8p23.1-2	0.0035
8	29293167	29574433	6				0.0064
12	46370995	47105108	10	103	9563151	12q13.11-3	0.0018
12	47191262	49654440	21				0.0022
12	49858115	51459707	21				0.0065
12	51492453	52261807	9				0.0025
12	52382320	54215964	23				0.0009
12	54367089	55934146	19				0.0044
16	11139	3142783	23	23	3131644	16p13.3	0.0091
17	9578676	15297799	54	54	5719123	17p12-13.1	0.0025
19	2122188	4798764	17	17	2676576	19p13.3	0.0045

Areas on chromosomes 1, 8, and 12 consist of multiple non-overlapping regions with differing copy numbers, whereas areas on chromosomes 16, 17, and 19 consist of single regions. Each row represents one region with constant calls across all samples. Sum of clones and length columns give the number of clones on all regions of each area and the total length of the area, respectively.

ISSN: 1465-542X