Brk-mediated signaling events are present in a human tissue array. A, Brk IHC in a human TMA. B, Phospho-p38 MAPK IHC in a human TMA. Graphs: IHC intensity plotted as a fraction of all tissue samples on the array, totaling 100%. Images: Representative images of IHC intensities in carcinoma samples. C, Brk and p-p38 MAPK co-staining in human TMA samples. Brk-positive tumors are 2.87 times more likely to be phospho-p38-positive than Brk-null tumors are likely to be phospho-p38-positive (P = 0.03). The 95% CI for the odds ratio is (1.10, 7.43).