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Table 7 ER+/PR+ subgroup-specific differences in serum U6, 5S, and other RNAs

From: Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients

Column ID

Pvalue

Fold change

Metastasis versus healthy

   U6

0.0024

3.26

   U6-SNORD44

0.003

4.18

   miR-16

0.001

2.83

   miR-16-SNORD44

0.002

3.65

   5S

0.0027

-21

   5S-SNORD44

0.007

-16

   SNORD44

0.275

-1.3

Cancer-free versus healthy

   U6

3.09 × 10-5

5.4

   U6-SNORD44

0.0002

6.35

   miR-16

0.004

2.46

   miR-16-SNORD44

0.01

2.9

   5S

0.05

-7.2

   5S-SNORD44

0.07

-6.16

   SNORD44

0.51

-1.17

Metastasis versus cancer-free

   U6

0.16

-1.68

   U6-SNORD44

0.37

-1.51

   miR-16

0.64

1.14

   miR-16-SNORD44

0.55

1.27

   5S

0.268

-2.93

   5S-SNORD44

0.326

-2.65

   SNORD44

0.66

-1.11

  1. Sera of patients with estrogen receptor/progesterone receptor-positive (ER/PR+) breast cancer were compared with those of healthy subjects (cohort 2). miR-16, microRNA 16; SNORD44, small nucleolar RNA 44.