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Table 5 Cancer subtype-specific differences in U6, 5S, and other RNAs compared with healthy subjects

From: Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients

Small RNA ER+/PR+ cancer versus healthy ER-/PR- cancer versus healthy
  P value Fold change P value Fold change
U6 0.01 2.16 0.004 3.03
5S 0.087 1.52 0.02 2.1
miR-21 0.52 -1.09 0.79 1.05
miR-16 0.614 -1.11 0.962 1.01
SNORD44 0.21 1.09 0.29 1.09
U6-miR-16 0.02 2.4 0.02 3.00
U6-SNORD44 0.02 2.0 0.008 2.77
5S-miR-16 0.07 1.7 0.05 2.08
5S-SNORD44 0.196 1.4 0.055 1.92
miR-21-miR-16 0.96 1.01 0.91 1.03
miR-21-SNORD44 0.273 -1.19 0.85 -1.04
  1. Small RNA levels in the serum of patients with estrogen receptor/progesterone receptor-positive (ER/PR+) or ER/PR- cancer were compared with those in the serum of healthy volunteers (experimental cohort). miR-16, microRNA 16; miR-21, microRNA 21; SNORD44, small nucleolar RNA 44.