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Table 5 Cancer subtype-specific differences in U6, 5S, and other RNAs compared with healthy subjects

From: Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients

Small RNA

ER+/PR+ cancer versus healthy

ER-/PR- cancer versus healthy

 

P value

Fold change

P value

Fold change

U6

0.01

2.16

0.004

3.03

5S

0.087

1.52

0.02

2.1

miR-21

0.52

-1.09

0.79

1.05

miR-16

0.614

-1.11

0.962

1.01

SNORD44

0.21

1.09

0.29

1.09

U6-miR-16

0.02

2.4

0.02

3.00

U6-SNORD44

0.02

2.0

0.008

2.77

5S-miR-16

0.07

1.7

0.05

2.08

5S-SNORD44

0.196

1.4

0.055

1.92

miR-21-miR-16

0.96

1.01

0.91

1.03

miR-21-SNORD44

0.273

-1.19

0.85

-1.04

  1. Small RNA levels in the serum of patients with estrogen receptor/progesterone receptor-positive (ER/PR+) or ER/PR- cancer were compared with those in the serum of healthy volunteers (experimental cohort). miR-16, microRNA 16; miR-21, microRNA 21; SNORD44, small nucleolar RNA 44.
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Breast Cancer Research

ISSN: 1465-542X

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