Table 1 Selected characteristics of cohort studies with quantitative classification of percent mammographic density
From: Mammographic density and breast cancer risk: current understanding and future prospects
Authors/study, region | Subject age, years | Sample sizea | Measurementb | Partitionc | OR (95% CI) | Follow-up, years | Adjustmentsd |
|---|---|---|---|---|---|---|---|
Kato et al. [7], USA | 35-65 | 197/521 | Planimetry | Upper versus lower tertile | 3.6 (1.4 to 9.1) | 5.5 | BMI, parity, and menopause |
Saftlas et al. [8], USA | 35-74 | 266/301 | Planimetry | <5% versus ≥65% | 4.3 (2.1 to 8.8) | 5 | Age, weight, and parity |
Byrne et al. [9], USA | 35-74 | 1,880/2,152 | Planimetry | 0% versus ≥75% | 4.3 (3.1 to 6.1) | 10 | Weight, age at first birth, family history, years of education, alcohol use, previous benign biopsies, and reproductive years |
Torres-Mejia et al. [10], Europe | 40-80 | 111/3,100 | Computer-assisted | 0.5% versus >46% | 3.5 (1.4 to 5.2) | 14 | Age, education, parity, height, and BMI |
van Gils et al. [11], Europe | >45 | 129/517 | Automated | <5% versus >25% | 2.9 (1.6 to 5.6) | 10 | Age and parity |
Thomas et al. [12], USA | <50 | 547/472 | Estimation | Upper versus lower quartiles | 4.4 (3.0 to 6.7) | >6 | Age and study |
Maskarinec et al. [13], USA | 60e | 607/667 | Computer-assisted | <10% versus >50% | 3.6 (2.3 to 5.6) | 7 | Ethnicity, age, BMI, age at first birth, number of births, age at menarche, age at menopause, HRT, and family history of breast cancer |
Boyd et al./NBSS [14], Canada | 40-59 | 330 | a. Estimation b. Computer-assisted | 0% versus ≥75% | a. 6.0 (2.8 to 13.0) b. 4.0 (2.1 to 7.7) | 7 | Age, parity, age at first birth, weight, height, number of births, age at menarche, and family history |
Boyd et al./SMPBC [15], Canada | 40-70 | 398 | a. Estimation b. Computer-assisted | <10% versus ≥75% | a. 4.5 (1.9 to 11.0) b. 4.4 (2.1 to 5.0) | 6 | Age, parity, age at first birth, weight, height, number of births, age at menarche, and family history |
Boyd et al./OBSP [15], Canada | 50-69 | 386 | a. Estimation b. Computer-assisted | <10% versus ≥75% | a. 3.4 (1.1 to 10.3) b. 4.1 (2.0 to 8.6) | 8 | Age, parity, age at first birth, weight, height, number of births, age at menarche, and family history |
Boyd et al./Combined [15], Canada | 40-70 | 1,114 | a. Estimation b. Computer-assisted | <10% versus ≥75% | a. 4.7 (3.0 to 7.4) b. 4.4 (2.9 to 6.7) | 6-8 | Age, parity, age at first birth, weight, height, number of births, age at menarche, and family history |