Skip to main content

Advertisement

Table 1 Selected characteristics of cohort studies with quantitative classification of percent mammographic density

From: Mammographic density and breast cancer risk: current understanding and future prospects

Authors/study, region Subject age, years Sample sizea Measurementb Partitionc OR (95% CI) Follow-up, years Adjustmentsd
Kato et al. [7], USA 35-65 197/521 Planimetry Upper versus lower tertile 3.6 (1.4 to 9.1) 5.5 BMI, parity, and menopause
Saftlas et al. [8], USA 35-74 266/301 Planimetry <5% versus ≥65% 4.3 (2.1 to 8.8) 5 Age, weight, and parity
Byrne et al. [9], USA 35-74 1,880/2,152 Planimetry 0% versus ≥75% 4.3 (3.1 to 6.1) 10 Weight, age at first birth, family history, years of education, alcohol use, previous benign biopsies, and reproductive years
Torres-Mejia et al. [10], Europe 40-80 111/3,100 Computer-assisted 0.5% versus >46% 3.5 (1.4 to 5.2) 14 Age, education, parity, height, and BMI
van Gils et al. [11], Europe >45 129/517 Automated <5% versus >25% 2.9 (1.6 to 5.6) 10 Age and parity
Thomas et al. [12], USA <50 547/472 Estimation Upper versus lower quartiles 4.4 (3.0 to 6.7) >6 Age and study
Maskarinec et al. [13], USA 60e 607/667 Computer-assisted <10% versus >50% 3.6 (2.3 to 5.6) 7 Ethnicity, age, BMI, age at first birth, number of births, age at menarche, age at menopause, HRT, and family history of breast cancer
Boyd et al./NBSS [14], Canada 40-59 330 a. Estimation b. Computer-assisted 0% versus ≥75% a. 6.0 (2.8 to 13.0) b. 4.0 (2.1 to 7.7) 7 Age, parity, age at first birth, weight, height, number of births, age at menarche, and family history
Boyd et al./SMPBC [15], Canada 40-70 398 a. Estimation b. Computer-assisted <10% versus ≥75% a. 4.5 (1.9 to 11.0) b. 4.4 (2.1 to 5.0) 6 Age, parity, age at first birth, weight, height, number of births, age at menarche, and family history
Boyd et al./OBSP [15], Canada 50-69 386 a. Estimation b. Computer-assisted <10% versus ≥75% a. 3.4 (1.1 to 10.3) b. 4.1 (2.0 to 8.6) 8 Age, parity, age at first birth, weight, height, number of births, age at menarche, and family history
Boyd et al./Combined [15], Canada 40-70 1,114 a. Estimation b. Computer-assisted <10% versus ≥75% a. 4.7 (3.0 to 7.4) b. 4.4 (2.9 to 6.7) 6-8 Age, parity, age at first birth, weight, height, number of births, age at menarche, and family history
  1. aReported as the number of case subjects/number of control subjects or as the number of pairs of case and control subjects. bEstimation means visual estimation by an observer (radiologist). cThe most and least extensive categories of density from which odds ratios (ORs) were calculated. dFactors included in the analysis of risk associated with mammographic density. Factors controlled for by matching are also included. eAverage age. Table reproduced from [2]. BMI, body mass index; CI, confidence interval; HRT, hormone replacement therapy; NBSS, National Breast Screening Study; OBSP, Ontario Breast Screening Program; SMPBC, Screening Mammography Program of British Columbia. Republished with permission from [2].