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Table 2 Comparison of CTC and DTC detection in breast cancer

From: Clinical relevance and biology of circulating tumor cells

    

n (%)

  

Detection method

Patient status

Remarks

Total number of patients

CTC+, DTC+

CTC+, DTC-

CTC-, DTC+

CTC-, DTC-

Concordance (%)

Reference

Pan-CK staining

M0 and M1

-

114

26 (22.8)

2 (1.7)

41 (35.9)

45 (39.4)

62.3

[35]

Pan-CK staining

M0 and M1

-

53

3 (5.6)

2 (3.7)

6 (11.3)

42 (79.2)

84.9

[21]

RT-PCR

M0 and M1

Detection of CK19

148

8 (5.4)

14 (9.5)

34 (22.9)

92 (62.2)

67.5

[33]

CK19 or mammaglobin

M0 and M1

Detection of mammaglobin

148

11 (7.4)

18 (12.2)

19 (12.8)

100 (67.6)

75.0

[33]

CK-staining

M0

-

341

8 (2.3)

26 (7.6)

40 (11.7)

267 (78.3)

80.6

[29]

Pan-CK staining

M0 and M1

-

39

12 (30.8)

3 (7.6)

12 (30.8)

12 (30.8)

61.5

[34]

RT-PCR, CK19

M0

Patients before neo-adjuvant therapy

165

88 (53.3)

3 (1.8)

7 (4.2)

67 (40.6)

93.9

[31]

  

Patients after neo-adjuvant therapy

84

32 (38.1)

12 (14.2)

11 (13.1)

29 (34.5)

72.6

[31]

CellSearch®, RT-PCR

M0

High-risk patients

27

16 (59.2)

4 (14.8)

3 (11.2)

4 (14.8)

74.1

[22]

Pan-CK staining, CellSearch®

M0

-

63

5 (7.9)

13 (20.6)

15 (23.8)

30 (47.6)

55.5

[18]

Avarage

       

72.8

 

Minimum

       

55.5

[18]

Maximum

       

93.9

[31]

  1. Abbreviations: M0, no detected metastasis; M1, metastasis; n, number of patients; RT-PCR, reverse transcription polymerase chain reaction.