Figure 1
From: Epithelial-mesenchymal transition, cancer stem cells and treatment resistance
Interaction between epithelial-mesenchymal transition and self-renewal pathways of cancer stem cells. ECM, extracellular matrix; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; FGF, fibroblast growth factor; HGF, hepatocyte growth factor; MMP, matrix metalloproteinase; PDGF, platelet-derived growth factor; PDK1, phosphoinositide-dependent kinase-1; PI3K, phosphatidylinositol-3-kinase; SMAD, Sma and Mad-related family; TCF, T-cell factor; TGF, transforming growth factor; VEGFR, vascular endothelial growth factor receptor; ZEB, zinc finger E-box binding homeobox.