Evaluation of prognostic and predictive value of microtubule associated protein tau in two independent cohorts

Breast Cancer Research

Table 7 Cox proportional hazards multivariate model in TAX 307S

	TAX 307S cohort
Variable	No. of patients (%) (n = 140)	HR	95% CI	P*
Age	108 (77.1)	0.972	0.934-1.011	0.153
Other	10 (7.1)
Unknown	22 (15.7)
Tumor size (cm)
≤ 2	24(17.1)	1.000		0.224
2-5	56 (40.0)	1.116	0.280-4.444
≥ 5	22 (15.8)	1.326	0.433-4.065
Other	15 (10.7)
Unknown	23 (16.4)
Nodal status
Negative for node metastasis	33 (23.6)	1.000		0.207
Positive for node metastasis	62 (44.3)	3.364	0.792-14.297
Other	23 (16.4)
Unknown	22 (15.7)
Tumor grade
Well/moderately differentiated	31 (22.1)	1.000		0.773
Poorly/undifferentiated	59 (42.1)	0.897	0.430-1.875
Other	28 (20.1)
Unknown	22 (15.7)
ER status
ER negative	40 (28.6)	1.000		0.524
ER positive	50 (35.7)	1.353	0.533-3.424
Other	28 (20.0)
Unknown	22 (15.7)
PR status
PR negative	41 (29.3)	1.000		0.751
PR positive	46 (32.9)	1.154	0.475-2.801
Other	31 (22.1)
Unknown	22 (15.7)
Prior adjuvant chemotherapy
No therapy	55 (39.3)	1.000		0.604
Yes therapy	53 (37.9)	0.835	0.422-1.650
Other	10 (7.1)
Unknown	22 (15.7)
Prior adjuvant hormonal therapy
No therapy	71 (50.7)	1.000		0.810
Yes therapy	37 (26.4)	0.909	0.417-1.980
Other	10 (7.1)
Unknown	22 (15.7)
Prior metastatic hormonal therapy
No therapy	80 (57.1)	1.000		0.456
Yes therapy	28 (20.0)	0.714	0.295-1.730
Other	10 (7.1)
Unknown	22 (15.7)
Treatment
FAC¹	54 (38.6)	1.000		0.264
TAC²	54 (38.6)	1.517	0.729-3.154
Other	10 (7.1)
Unknown	22 (15.7)
MAP-tau expression
MAP-tau low expression	73 (52.1)	1.000		0.007
MAP-tau high expression	35 (25.0)	0.308	0.130-0.728
Other	10 (7.1)
Unknown	22 (15.7)

*P is given for Cox multivariate analysis, statistically significant P values (P < 0.05) are in boldface, trending values are in italics; CI, confidence interval; ER, estrogen receptor; HR, hazard ratio; PR, progesterone receptor.
¹FAC, 5-fluorouracil-doxorubicin-cyclophosphamide combination.
²TAC, docetaxel-doxorubicin-cyclophosphamide combination.

ISSN: 1465-542X