Table 4 Cox proportional hazards multivariate model for overall survival in the Yale University cohort

Age at diagnosis

645 (99.1)

1.004

0.981-1.026

0.718

Unknown

6 (0.9)

Menopausal status

Premenopausal

196 (30.1)

1.000

0.339

Postmenopausal

449 (69.0)

1.158

0.857-1.569

Other

6 (0.9)

Tumor size (cm)

≤ 2

215 (33.0)

1.000

< 0.0001

2-5

283 (43.5)

1.880

1.255-2.865

≥ 5

101 (15.5)

1.988

1.323-2.951

Unknown

52 (8.0)

Nodal status

Negative for node metastasis

327 (50.2)

1.000

< 0.0001

Positive for node metastasis

320 (49.2)

1.578

1.307-1.922

Unknown

4 (0.6)

Total nodes

625 (96.0)

0.976

0.956-0.996

0.022

Unknown

26 (4.0)

Nuclear grade

Small/uniform nuclei

113 (17.4)

1.000

0.421

Intermediate nuclei

315 (48.4)

1.015

0.624-1.725

Large nuclei

170 (26.1)

1.272

0.868-1.853

Unknown

53 (8.1)

ER status

ER negative

289 (44.4)

1.000

0.308

ER positive

326 (50.1)

0.903

0.740-1.097

Unknown

36 (5.5)

PR status

PR negative

294 (45.2)

1.000

0.433

PR positive

302 (46.4)

0.929

0.769-1.114

Unknown

55 (8.4)

HER2 status

HER2 negative

495 (76.0)

1.000

0.020

HER2 positive

109 (16.7)

1.292

1.041-1.586

Unknown

47 (7.2)

MAP-tau expression

MAP-tau low expression

376 (57.8)

1.000

0.018

MAP-tau high expression

104 (16.0)

0.765

0.598-0.957

Other

171 (26.3)