Figure 5
From: β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib
β1 inhibition overcomes resistance to potent LT therapy in HCC1954 cells. (A) HCC1954 parental and LTRes were plated on lrECM in the presence of LT and assayed for growth response. (B) Cells were plated on lrECM, subjected to either AIIB2 or IgG control, and imaged after 12 days. (C) Cultures were grown in the presence of appropriate inhibitors for five days and immunostained with Ki67 or TUNEL reagent as before.