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Figure 5 | Breast Cancer Research

Figure 5

From: The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions

Figure 5

Mcs5a is associated with an increased CD3+ T-cell abundance attributable to increased γδTCR+ T-cell abundance in the mammary epithelium of DMBA-treated rats as compared with untreated rats. (a) Percentage of CD3+, CD4+, CD8+, or γδTCR+ T cells of total cells. Values are expressed as average ± standard error of the mean. Significantly higher (P < 0.05) percentages in the Mcs5a-resistant congenic rat line (Mcs5a, filled bars; -DMBA n = 6, +DMBA n = 12) compared with the susceptible congenic control line (susc., open bars; -DMBA n = 6, +DMBA n = 12) are indicated by an asterisk. Significantly higher (P < 0.05) percentage of T-cell abundance upon DMBA treatment compared with no treatment is indicated by two asterisks. (b) Infiltrating T cells in frank mammary carcinomas of susceptible (open bars, n = 11) and Mcs5a-resistant congenic rat line (filled bars, n = 12) rats. Significantly higher (P < 0.05) percentages in the Mcs5a-resistant congenic rat line compared with the susceptible congenic control line are indicated by an asterisk. (c) Expression of CD4, CD8, and CD161α on γδTCR+ T cells in mammary gland and spleen of susceptible (open bars, n = 6) and Mcs5a-resistant congenic rat line (filled bars, n = 7) rats. DMBA, 7,12-dimethylbenz(a)anthracene; Mcs5a, mammary carcinoma susceptibility locus 5a; TCR, T-cell receptor.

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Breast Cancer Research

ISSN: 1465-542X

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