Skip to main content
Figure 5 | Breast Cancer Research

Figure 5

From: Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells

Figure 5

Roscovitine treatment reduces proliferation and increases apoptosis in endocrine-resistant xenografts. (a) Immunohistochemical analysis of Proliferating Cell Nuclear Antigen (PCNA) on tumors treated with or without roscovitine. (b) Quantitation of PCNA staining using the PCNA index. P, P value; ** P < 0.01, * P < 0.05. (c) TUNEL staining for apoptosis in control and roscovitine-treated tumors. Representative images are depicted (upper panel). Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) labeling was quantified as the mean TUNEL labeling percentage based on at least three randomly selected high-power microscope fields per group (lower panel). P, P value; ** P < 0.01, * P < 0.05. (d) Immunohistochemical analysis for estrogen receptor (ERα) status was performed in groups with or without roscovitine treatment. Con, control; ROS, roscovitine.

Back to article page