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Figure 1 | Breast Cancer Research

Figure 1

From: Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR)

Figure 1

Quantitative Real-Time PCR analysis of SMAD3 and SMAD4 germline expressions. The mean expressions of four separate groups of mRNA are compared for (A) SMAD3 and (B) SMAD4. The BC-VAR (Breast Cancer-Variants) group represents cases harboring variants; the BC-REF (Breast Cancer - Reference) group represents the cases where variants were not detected. The CO-VAR (Control-Variants) group represents controls harboring variants; CO-REF (Control-Reference), represents controls where variants were not detected. P5 and P9 represent familial breast cancer cases exhibiting high germline expression with the latter harboring the novel c.1350G > A alteration. Statistical significance was determined by the Mann-Whitney test of independence with error bars representing standard deviation (SD). The upper and lower boundaries of the box indicate 75th and 25th percentiles, respectively. The line within the box represents the median; bars above and below the box, the 90th and 10th percentiles, respectively.

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Breast Cancer Research

ISSN: 1465-542X

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