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Figure 5 | Breast Cancer Research

Figure 5

From: Analysis of EpCAM positive cells isolated from sentinel lymph nodes of breast cancer patients identifies subpopulations of cells with distinct transcription profiles

Figure 5

EpCAM enrichment by IMS enriched for cells expressing transcripts associated with EMT. All graphs show expression results from 17 EMT arrays representing EpCAM+/hMAM+ cells (first five arrays), EpCAM+/hMAM- cells (next five arrays) and EpCAM depleted cells (last seven arrays). Several transcripts were significantly higher expressed in all EpCAM+ fractions compared with the EpCAM depleted cells. This applied to EGFR, MITF and SPARC (upper panel), members of the metalloproteinase family (middle panel), collagens Col1A2 and Col3A1 and desmocollin (DSC2, lower panel). Note: sample G+ expressed more EGFR (actual value 419), but this is shortened to fit in the graph. Fold change is calculated relative to the average expression of each gene.

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Breast Cancer Research

ISSN: 1465-542X

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