Table 3 Hazard ratiosa according to tertiles of serum 25(OH)D and time between diagnosis and blood collection
Serum 25(OH)D | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Continuous | Categorized | ||||||||||||
per 10 nmol/L decrement | < 35 nmol/L | 35-55 nmol/L | ≥ 55 nmol/L | ||||||||||
Outcome | No. (events) | HR | 95% CI | P trend b | No. (events) | HR | 95% CI | No. (events) | HR | 95% CI | No. (events) | HR | 95% CI |
Overall mortality | |||||||||||||
All | 1,265 (174) | 1.08 | 1.00 to 1.17 | 0.07 | 422 (82) | 1.55 | 1.00 to 2.39 | 397 (44) | 0.72 | 0.45 to 1.17 | 446 (48) | 1.00 | - |
< 2 years | 1,249 (172) | 1.09 | 1.00 to 1.17 | 0.05 | 418 (82) | 1.57 | 1.01 to 2.43 | 394 (44) | 0.75 | 0.46 to 1.22 | 437 (46) | 1.00 | - |
< 1 year | 1,093 (151) | 1.13 | 1.03 to 1.22 | 0.02 | 375 (77) | 1.81 | 1.11 to 2.94 | 353 (39) | 0.82 | 0.48 to 1.42 | 365 (35) | 1.00 | - |
< 0.5 year | 807 (119) | 1.15 | 1.03 to 1.26 | 0.02 | 277 (63) | 2.19 | 1.21 to 3.97 | 275 (33) | 0.96 | 0.50 to 1.83 | 255 (23) | 1.00 | - |
Distant disease | |||||||||||||
All | 1,074 (135) | 1.14 | 1.05 to 1.24 | 0.006 | 338 (63) | 2.09 | 1.29 to 3.41 | 342 (37) | 1.16 | 0.70 to 1.94 | 394 (35) | 1.00 | - |
< 2 years | 1,059 (133) | 1.15 | 1.05 to 1.25 | 0.005 | 335 (63) | 2.11 | 1.30 to 3.45 | 339 (37) | 1.17 | 0.70 to 1.95 | 385 (33) | 1.00 | - |
< 1 year | 925 (119) | 1.15 | 1.05 to 1.26 | 0.007 | 298 (59) | 2.24 | 1.32 to 3.79 | 302 (32) | 1.28 | 0.74 to 2.22 | 325 (28) | 1.00 | - |
< 0.5 year | 685 (95) | 1.13 | 1.01 to 1.25 | 0.05 | 219 (48) | 2.16 | 1.18 to 3.98 | 235 (25) | 1.12 | 0.60 to 2.10 | 231 (22) | 1.00 | - |