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Table 3 Breast cancer risk associated with each group of ATM variants

From: Rare variants in the ATMgene and risk of breast cancer

Group Number of Variants Cases Controls Odds Ratio 95% confidence interval
No variant (referent) - 2,423 1,367 1.0  
Group 1 19 79 45 0.99 0.67-1.45
Group 2 8 59 334 1.10 0.71-1.70
Group 3 3 9 2 2.55 0.54-12.0
  1. Group 1 includes all rare variants classified by the A-GVGD algorithm as C0; Group 3 includes all rare variants that are C55/C65 in either the FAT or kinase domains of the ATM protein as well as all truncating variants and splice variants at the consensus sites. Group 2 includes all other rare variants (see Additional file 1 for details). ATM, Ataxia telangiectasia mutated.
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