Group
|
Number of Variants
|
Cases
|
Controls
|
Odds Ratio
|
95% confidence interval
|
---|
No variant (referent)
|
-
|
2,423
|
1,367
|
1.0
| |
Group 1
|
19
|
79
|
45
|
0.99
|
0.67-1.45
|
Group 2
|
8
|
59
|
334
|
1.10
|
0.71-1.70
|
Group 3
|
3
|
9
|
2
|
2.55
|
0.54-12.0
|
- Group 1 includes all rare variants classified by the A-GVGD algorithm as C0; Group 3 includes all rare variants that are C55/C65 in either the FAT or kinase domains of the ATM protein as well as all truncating variants and splice variants at the consensus sites. Group 2 includes all other rare variants (see Additional file 1 for details). ATM, Ataxia telangiectasia mutated.