Skip to main content


Figure 4 | Breast Cancer Research

Figure 4

From: Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10

Figure 4

Response of skin fibroblast cultures with high and low FGFR2 mRNA levels to stimulation with ligand FGF2. Phosphorylation of downstream targets FRS2α and ERK1/2 were measured before and after 10 minutes of stimulation with FGF2. The average difference of the increase in phosphorylation is shown, which was calculated by dividing the increase in samples with high FGFR2 mRNA levels by the increase in samples with low FGFR2 mRNA levels. The 95% confidence intervals are also shown. Phosphorylation of FRS2α was measured in four fibroblast cultures: two with high and two with low FGFR2 mRNA levels. Phosphorylation of ERK1/2 was measured in 10 fibroblast cultures, five with high and five with low FGFR2 mRNA levels.

Back to article page