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Table 2 Mean survival in correlation to CTC positivity, TIMP-1 and CAIX levels

From: Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer

  PFS in months Pvalue OS in months Pvalue
CTC     
   < 5 cells 10.9 (9.4-12.5) 0.118 20.1 (18.8-21.5) < 0.01
   ≥ 5 cells 9.3 (7.8-10.9)   14.0 (12.8-21.5)  
TIMP-1     
   Non elevated 11.4 (10.1-12.7) < 0.01 19.1 (18.0-20.3) < 0.01
   Elevated 7.2 (5.6-8.9)   11.5 (9.4-13.6)  
CAIX     
   Non elevated 11.7 (10.3-13.1) < 0.01 19.1 (17.8-20.4) < 0.01
   Elevated 7.5 (6.0-9.0)   13.4 (11.4-15.4)  
TIMP-1/CAIX     
   Both non-elevated 12.4 (10.9-13.9) < 0.01 20.1 (18.8-21.3) < 0.01
   Both elevated 7.0 (5.0-9.0)   11.1(8.5-13.6)  
  1. CAIX, carbonic anhydrase IX; CTC, circulating tumor cell; OS, overall survival; PFS, progression-free survival; TIMP, tissue inhibitor of metalloproteinase.