Figure 6
From: Applications of microarray technology in breast cancer research
The use of an Affymetrix DNA microarray to sequence the BRCA1 gene. The array is hybridised with a mixture of normal DNA (green) and test DNA from a carrier of the BRCA1 mutation (red). Equal hybridisation to the two probes gives yellow. (a) Composite image of hybridisation to normal control and test DNA. (b) Magnification of the region surrounding the 2,457 C→T mutation. (c) Close-up of the probe sets surrounding the 2,457 C→T mutation. The bright red signal indicates the presence of the mutation. Taken from [42].