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Table 2 Multivariate analysis for prognostic factors in 549 patients aged less than 40 years

From: Impact of established prognostic factors and molecular subtype in very young breast cancer patients: pooled analysis of four EORTC randomized controlled trials

  Overall survival Distant disease-free survival
  HR 95% CI P HR 95% CI P
pT2 + pT3 1.68 1.12 to 2.52 0.01 1.61 1.14 to 2.25 0.006
pN + 2.62 1.31 to 5.23 0.006 2.21 1.24 to 3.96 0.008
Lymphangio invasion    0.75    0.73
   No vessels 1    1   
   1 to 5 vessels 0.93 0.53 to 1.62   0.97 0.61 to 1.53  
   > 5 vessels 1.18 0.71 to 1.97   1.17 0.75 to 1.83  
Molecular subtype    0.02    0.06
   Basal 1    1   
   Luminal A 0.50 0.29 to 0.86   0.69 0.44 to 1.08  
   HER2 0.42 0.17 to 1.04   0.45 0.21 to 0.99  
   Luminal B 0.92 0.56 to 1.48   1.01 0.67 to 1.53  
Breast conserving therapy 0.76 0.47 to 1.24 0.27 0.81 0.53 to 1.23 0.33
Adjuvant chemotherapy 0.68 0.35 to 1.33 0.26 0.65 0.37 to 1.13 0.13
  1. Abbreviations: HR, hazard ratio; CI, confidence interval.