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Table 2 Multivariate analysis for prognostic factors in 549 patients aged less than 40 years

From: Impact of established prognostic factors and molecular subtype in very young breast cancer patients: pooled analysis of four EORTC randomized controlled trials

 

Overall survival

Distant disease-free survival

 

HR

95% CI

P

HR

95% CI

P

pT2 + pT3

1.68

1.12 to 2.52

0.01

1.61

1.14 to 2.25

0.006

pN +

2.62

1.31 to 5.23

0.006

2.21

1.24 to 3.96

0.008

Lymphangio invasion

  

0.75

  

0.73

   No vessels

1

  

1

  

   1 to 5 vessels

0.93

0.53 to 1.62

 

0.97

0.61 to 1.53

 

   > 5 vessels

1.18

0.71 to 1.97

 

1.17

0.75 to 1.83

 

Molecular subtype

  

0.02

  

0.06

   Basal

1

  

1

  

   Luminal A

0.50

0.29 to 0.86

 

0.69

0.44 to 1.08

 

   HER2

0.42

0.17 to 1.04

 

0.45

0.21 to 0.99

 

   Luminal B

0.92

0.56 to 1.48

 

1.01

0.67 to 1.53

 

Breast conserving therapy

0.76

0.47 to 1.24

0.27

0.81

0.53 to 1.23

0.33

Adjuvant chemotherapy

0.68

0.35 to 1.33

0.26

0.65

0.37 to 1.13

0.13

  1. Abbreviations: HR, hazard ratio; CI, confidence interval.